A Quick Note Before You Begin In the span of just a few years, the medical weight loss landscape has been completely rewritten by a new class of medications. Semaglutide reset expectations in 2021. Tirzepatide pushed them further in 2022 and 2023. By late 2026, a third contender is reshaping the conversation again: retatrutide, a triple-agonist molecule with the most impressive early clinical data of any weight management medication to date. For patients considering medical w