How Much Weight Can You Lose with Tirzepatide in One Year?

Tirzepatide has become one of the most talked-about medications for weight loss, and for good reason. With celebrities and doctors alike backing its effectiveness, many are now asking the same question: How much weight can I realistically lose with tirzepatide in a year?

Whether you're just exploring your options or already on a structured weight loss plan like SHAPE Ultra, understanding the timeline and expectations with tirzepatide can help you make informed decisions about your journey.

1. What Is Tirzepatide?

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, originally developed for type 2 diabetes. But its potent effects on appetite suppression and fat metabolism have made it a leading option for medical weight loss.

It’s administered weekly and works by:

• Slowing gastric emptying (you feel fuller, longer)

• Reducing cravings and hunger

• Improving insulin sensitivity

2. Clinical Results: How Much Weight You Can Lose in 1 Year with Tirzepatide?

In clinical trials like the SURMOUNT-1 study, adults with obesity or overweight (without diabetes) lost an average of:

• 15% of their body weight in 1 year on a high dose of tirzepatide (15 mg/week)

• Some participants lost more than 20%

To put that into perspective:

• A 90 kg individual could lose up to 13.5 kg to 18 kg in one year.

Source: Jastreboff, A. M., et al. (2022). New England Journal of Medicine, 387(3), 205–216. Link to study

3. Real-World Weight Loss Results in the Philippines

While the clinical trials offer clear benchmarks, many Filipinos are wondering what these results mean locally.

In Manila and across the Philippines, real-world results are showing weight loss averages between 8% to 15% in the first 6 months, especially when combined with nutritional coaching and structured support like in SHAPE Ultra.

Why the variation? Factors include:

• Dosage tolerance

• Lifestyle and eating habits

• Stress and sleep patterns

• Consistency in follow-ups

4. Why You Might Lose Less Than Expected

The Cleveland Clinic's 2025 real-world study found that weight loss in everyday users tends to be less than in clinical trials, due to:

• Missed doses or early discontinuation

• Lower maintenance doses

• Lack of structured behavioral support

Source: Cleveland Clinic (2025). Real-World Use of GLP-1 and GIP-1 Agonists. newsroom.clevelandclinic.org

5. What to Expect Month-by-Month

Month	What Happens
1	Reduced appetite, mild nausea, slow but noticeable drop in water weight
2–3	Steady fat loss starts, especially with structured meals
4–6	Visible results in body composition; may hit 10% loss
7–12	Slower but continued loss, body adapts; some plateauing may occur

Tip: This is where structured support matters most to break plateaus and maintain motivation.

6. Can You Maximize Results With Lifestyle Changes?

Yes. Tirzepatide is not magic, but it becomes incredibly effective when used in tandem with diet, movement, and recovery strategies.

Here’s what works:

• High-protein, low-glycemic meals

• Strength training at least 2–3x a week

• Proper hydration and sleep

• Mindful eating to retrain food behavior

7. What If You Plateau?

Many patients notice slower progress after 6 months. This is completely normal. It often signals:

• Loss of water weight has stabilized

• Metabolism is adjusting

• Behavioral patterns need tweaking

• 
  

In these cases, adjustments in dose and personalized tweaks (like adding magnesium or SPM supplements) may help — which brings us to structured support.

8. SHAPE Ultra: Designed for Results Beyond Medication

The SHAPE Ultra Program by Jan Medical Group goes beyond the weekly injection.

It’s designed for individuals who want long-term success, not just temporary weight loss.

🔹 Weekly tirzepatide + medical coaching

🔹 InBody tracking and appetite regulation tools

🔹 Metagenics anti-inflammatory supplements (like SPM Active and Mag Glycinate)

🔹 Guidance on stress, sleep, and cravings

Clients who joined SHAPE Ultra have reported smoother transitions, fewer side effects, and more sustainable habits.

9. Final Thoughts

Tirzepatide has changed the weight loss game — but real results happen when medication meets mindset and method.

A full year on tirzepatide can help you lose 15–20% of your body weight, but only if supported by lifestyle changes and expert care.

How Our Weight Loss Clinic in Manila Approaches It

At our weight loss clinic in Metro Manila, we’ve seen firsthand how tirzepatide transforms the journey, not just the number on the scale, but also confidence, energy, and health markers like blood pressure and cholesterol.

Our SHAPE Ultra Program integrates medical weight loss with behavioral coaching, lab monitoring, and structured lifestyle changes to ensure long-term results. Tirzepatide isn’t a shortcut. It’s a scientifically backed tool, best combined with professional guidance and patient accountability.

Ready to Start?

Explore the SHAPE Ultra Program and see how sustainable weight loss can happen with a team behind you.

Visit our weight loss clinic in Quezon City or explore the SHAPE Ultra program at janmedicalgroup.ph/shape-programs/shape-ultra

You may also book an online or in-clinic weight loss consult here: https://www.janmedicalgroup.ph/consultations