Mesolipo and GLP-1: The New Combo for Targeted Fat Loss in 2025

Christian Peralta
6 days ago
3 min read

Looking for a way to finally get rid of stubborn fat? You’re not alone. In 2025, one of the top trends in non-surgical fat loss is the combination of GLP-1 medications like tirzepatide and Mesolipo + Exilis treatments, offered together in premier weight loss clinics in Metro Manila like Jan Medical Group.

This science-backed combo does more than help you lose weight, It reshapes your body with precision, especially in areas diet and exercise often miss.

What is a GLP-1 Medication and Why is Tirzepatide So Popular?

GLP-1 receptor agonists like tirzepatide are advanced injectable medications that:

Reduce hunger and slow digestion
Control blood sugar and insulin spikes
Promote long-term weight loss

Tirzepatide (part of the SHAPE Ultra program) mimics hormones your gut releases after eating. This helps your brain feel full faster, so you eat less—without relying on willpower alone.

A 2022 study published in The New England Journal of Medicine found patients on tirzepatide lost up to 22.5% of their body weight over time. That’s significantly more than what older medications achieved.

a box on a marble top. on the background are towels, and candles.

What is Mesolipo, and What Can It Target?

Mesolipo (mesotherapy for fat loss) is a minimally invasive procedure that uses injections to dissolve local fat deposits. It’s perfect for:

Double chin
Lower belly
Bra fat
Love handles
Thighs or arms

At Jan Medical Group, our JAN Mesolipo treatment is customized per body area using clinical-grade compounds that dissolve fat cells safely. It’s part of our Mesolipo + Exilis bundle, designed for both fat melting and skin tightening.

Why Add Exilis? Here's What Most People Overlook

Losing fat without tightening skin can sometimes leave sagging or loose areas, especially if you're over 30 or have experienced significant weight loss. This is where BTL Exilis Ultra 360 makes a huge difference.

Exilis is a non-invasive device that uses radiofrequency and ultrasound to:

Firm and tighten skin
Stimulate collagen production
Improve texture and tone

With JAN Mesolipo, each program includes Exilis skin tightening to ensure you look sculpted, not deflated.

exilis device on a woman's abdomen getting treatment

Why Combine GLP-1 Medications with JAN Mesolipo?

Here’s the science-backed reason: GLP-1 medications reduce overall weight, while Mesolipo + Exilis refine your shape.

GLP-1 Meds (like Tirzepatide)	JAN Mesolipo (Meso + Exilis)
Reduces appetite and food intake	Targets localized fat deposits
Lowers total and visceral fat	Firms and tightens skin
Improves insulin sensitivity	Works on problem areas directly
Ideal for whole-body fat loss	Ideal for facial/body contouring

When combined, these treatments complement each other beautifully. Your body shrinks with GLP-1, and Mesolipo + Exilis shape it into your ideal version—non-surgically and safely.

Who Benefits from This Combo?

This fat-loss protocol is perfect for:

✅ Individuals preparing for events (weddings, travels, photoshoots)

✅ Women and men aged 30–50 wanting targeted sculpting

✅ People with resistant fat in specific areas

✅ Clients who want visible results fast without downtime

Whether you’ve plateaued on your weight loss journey or want to level up your transformation, this approach is backed by clinical research and real-world success stories at Jan Medical Group.

What Does the SHAPE Ultra Program Include?

SHAPE Ultra is Jan Medical Group’s premium medical weight loss program, which includes:

Weekly tirzepatide injections (GLP-1)
Lifestyle consultations with obesity medicine doctors
Optional JAN Mesolipo + Exilis bundles for targeted areas
Access to the JMG Shop for approved supplements

Everything is coordinated by a weight loss clinic team in Manila, ensuring safety, personalization, and results.

How Many Sessions Are Needed?

🔹 GLP-1: Typically done weekly with dose titration

🔹 Mesolipo + Exilis: Most clients do 1–3 sessions, spaced 2–3 weeks apart, depending on goals.

Where to Get It

At Jan Medical Group, we specialize in body contouring and medical weight loss. Our expert doctors offer SHAPE Ultra and JAN Mesolipo to help you reach your dream shape faster.

We're a leading weight loss clinic in Metro Manila offering advanced, safe, and non-surgical solutions for fat loss, contouring, and total wellness.